Recently, several cis-regulatory elements that play roles in LHβ gene expression, and their
cognate DNA-binding transcription factors, have been identified. These factors include Sp1 …

Recent in vivo and in vitro studies have implicated the orphan nuclear receptor,
steroidogenic factor-1 (SF-1), and the early growth response protein 1 (Egr-1) in the …

The hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in
reproductive function by regulating the biosynthesis and secretion of the pituitary …

We have previously shown that early growth response (Egr) 1-deficient mice exhibit female
infertility, reflecting a luteinizing hormone (LH) β deficiency. Egr-1 activates the LHβ gene in …

Tight regulation of luteinizing hormone-β subunit (LHβ) expression is critical for
differentiation and maturation of mammalian sexual organs and reproductive function. Two …

Analysis of luteinizing hormone (LH) β subunit promoters from a broad range of species
including teleosts and humans revealed strict conservation of a sequence homologous to …

The gonadotrope-specific and regulated expression of the GnRH receptor (GnRH-R) gene is
dependent on multiple transcription factors that interact with the noncanonical GnRH-R …

Transcription of the luteinizing hormone receptor gene is dependent on Sp1-induced
promoter activation from two Sp1 binding domains (Sp1 2 and Sp1 4) within the 173-base …

Expression of the GnRH receptor (GnRH-R) gene in the anterior pituitary gland, as with the
genes encoding the gonadotropin subunits, is restricted to gonadotrophs. Thus, it is …

LH and FSH play critical roles in mammalian reproduction by mediating steroidogenesis and
gametogenesis in the gonad. Gonadal steroid hormone feedback to the hypothalamus and …