Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …

Mammalian embryos are formed by fusion of eggs and sperm. Here we provide an
integrated overview of the major dynamic changes in transcriptional processes, chromatin …

The seminal question in modern developmental biology is the origins of new life arising from
the unification of sperm and egg. The roots of this question begin from 19th to 20th century …

In many organisms, the transition from oocyte to embryo occurs in the absence of mRNA
transcription. Therefore, early developmental programs rely on maternal mRNAs and …

The oocyte-to-embryo transition (OET) arguably initiates with formation of a primordial
follicle and culminates with reprogramming of gene expression during the course of zygotic …

Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …

A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram
one type of cell into another. The transcription factors that reprogram cell fate are invariably …

In mammals, germ cells are induced from a population of cells at the base of the allantois.
This regulative mechanism of germ line induction depends on Bmp signals and a …

Although genetic mutations have long been known to influence gene expression and
individual phenotype, studies emerging over the past decade indicate that such changes …

Targeted mRNA translation is emerging as a critical mechanism to control gene expression
during developmental processes. Exciting new findings have revealed a critical role for …