Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Although the precise etiology of MS remains unclear, CD4+ T cells have been …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS), which involves autoimmune responses to myelin antigens. Studies in …

Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because
of the findings that the strongest genetic risk for MS is the major histocompatibility complex …

Multiple sclerosis (MS) is the most common human demyelinating disease of the central
nervous system. It is universally accepted that the immune system plays a major role in the …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, and
the imbalance between autoimmunity and immune tolerance is considered to be the key …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …