Ultraviolet A (UVA) radiation represents more than 90% of the solar UV radiation reaching
Earth's surface. Exposure to solar UV radiation is a major risk in the occurrence of non …

Exposure to solar UV radiation is the origin of most skin cancers, including deadly
melanomas. Melanomas are quite different from keratinocyte-derived tumours and exhibit a …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Despite the predominance of UVA relative to UVB in terrestrial sunlight, solar mutagenesis
in humans and rodents is characterized by mutations specific for UVB. We have investigated …

It is well established, at least in mice, that not only ultraviolet C (UVC) or ultraviolet B (UVB),
but also ultraviolet A (UVA) is able to induce squamous cell carcinomas. Results from animal …

Keratinocytes and melanocytes, two cutaneous cell types located within the epidermis, are
the origin of most skin cancers, namely carcinomas and melanomas. These two types of …

UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left
unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express …

Solar radiation is the main source of exposure to UV radiation and sufficient evidence for its
carcinogenicity in humans has been provided [1]. Solar UV radiation reaching the Earth …

Exposure to solar UV radiation gives rise to mutations that may lead to skin cancer. UVA
(320− 340 nm) constitutes the large majority of solar UV radiation but is less effective than …