Simple Summary High T-cell infiltration has been associated with improved clinical
outcomes in many human solid tumors. However, these cells are not autonomous in their …

To gain new insights into the functional interaction between DC and neoplastic cells, we
have analyzed the effects of melanoma and colorectal cancer lines on the chemotaxis and …

Dendritic cells (DCs) are central regulators of the adaptive immune response, and as such
are necessary for T-cell-mediated cancer immunity. In particular, antitumoral responses …

Several studies indicate that most tumours are immunogenic and they rarely succeed to
induce an efficient immune response. Many mechanisms have been involved in the tumour …

Among all immune cells, dendritic cells (DC) are the most potent APCs in the immune
system and are central players of the adaptive immune response. There are phenotypically …

Colorectal cancer (CRC) remains a devastating human malignancy with poor prognosis. Of
the various factors, immune evasion mechanisms play pivotal roles in CRC progression and …

Human dendritic cells (DCs) infiltrate solid tumors, but this infiltration occurs in favorable and
unfavorable disease prognoses. The statistical inference is that tumor-infiltrating DCs …

Overcoming local immunosuppression is critical for immunotherapy to produce robust anti-
tumor responses. Myeloid-derived suppressor cells (MDSCs) are key regulators of …

Dendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as
“natural adjuvants” for the induction of primary T or T-dependent immunity. DCs in the …

The failure of the immune system to provide protection against tumour cells is an important
immunological problem. It is now evident that inadequate function of the host immune …