Dendritic cells (DCs) are acknowledged as the most potent professional antigenpresenting
cells (APCs), able to induce adaptive immunity and support the innate immune response. In …

The vast majority of cancer-related deaths are due to metastasis, a process that requires
evasion of the host immune system. In addition, a significant percentage of cancer patients …

Immune suppression remains a consistent obstacle to successful anti-tumor immune
responses. As tumors develop, they create a microenvironment that not only supports tumor …

Simple Summary The tumor immune contexture plays a pivotal role for the clinical outcome
of cancer patients and the efficacy of various treatment modalities. Dendritic cells (DCs) …

Dendritic cells (DCs) are central to the adoptive immune response, and their function is
regulated by diverse signals in a context-specific manner. Different DCs have been …

Dendritic cells (DCs), the strongest antigen-presenting cells, are a focus for orchestrating the
immune system in the fight against cancer. Basic scientific investigations elucidating the …

The ability to mount an effective anti-tumor immune response requires coordinate control of
CD4 T cell and CD8 T cell function by antigen presenting cells (APCs). Unfortunately, tumors …

DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated
DCs can produce large amounts of various proinflammatory cytokines, initiate T‐cell …

In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

The use of patient-derived dendritic cells (DCs) as a means to elicit therapeutically relevant
immune responses in cancer patients has been extensively investigated throughout the past …