Cell type–specific association of hypoxia-inducible factor-1α (HIF-1α) protein accumulation and radiobiologic tumor hypoxia

D Vordermark, A Katzer, K Baier, P Kraft… - International Journal of …, 2004 - Elsevier
PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is currently
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …

Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies

D Vordermark, JM Brown - … Journal of Radiation Oncology* Biology* Physics, 2003 - Elsevier
PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is a key
regulatory element of the hypoxic response of cells. High protein levels have been linked to …

Basal HIF-1 [alpha] expression levels are not predictive for radiosensitivity of human cancer cell lines

D Schilling, C Bayer, K Emmerich… - Strahlentherapie …, 2012 - search.proquest.com
High levels of hypoxia inducible factor (HIF)-1α in tumors are reported to be associated with
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …

Dysregulation of Hypoxia Inducible Factor‐1α in Head and Neck Squamous Cell Carcinoma Cell Lines Correlates With Invasive Potential

NA Cohen, SY Lai, AF Ziober, BL Ziober - The Laryngoscope, 2004 - Wiley Online Library
Abstract Objectives/Hypothesis Tumor hypoxia appears to be closely associated with tumor
propagation, malignant progression, and resistance to radiotherapy. Hypoxia inducible …

Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1α (HIF-1α)

D Vordermark, P Kraft, A Katzer, T Bölling, J Willner… - Cancer letters, 2005 - Elsevier
Hypoxia-inducible factor-1α (HIF-1α) is both a potential endogenous marker of tumor
hypoxia and therapeutic target, and elevated HIF-1α protein levels have been shown to be …

Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

DM Aebersold, P Burri, KT Beer, J Laissue, V Djonov… - Cancer research, 2001 - AACR
Hypoxia has long been recognized as detrimental to the successful treatment of malignant
tumors with ionizing radiation. Because hypoxia-inducible factor (HIF)-1α plays an essential …

The hypoxia-inducible factor-1α is a negative factor for tumor therapy

A Unruh, A Ressel, HG Mohamed, RS Johnson… - Oncogene, 2003 - nature.com
Tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by
increasing the expression of genes encoding angiogenic, metabolic and metastatic factors …

Hypoxia-inducible factors HIF-1α and HIF-2α in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients

NJP Beasley, R Leek, M Alam, H Turley, GJ Cox… - Cancer research, 2002 - AACR
Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response
to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear …

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

KJ Williams, BA Telfer, D Xenaki, MR Sheridan… - Radiotherapy and …, 2005 - Elsevier
BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …

Oncological implications of hypoxia inducible factor-1α (HIF-1α) expression

JL O'Donnell, MR Joyce, AM Shannon, J Harmey… - Cancer treatment …, 2006 - Elsevier
Solid tumours contain regions of hypoxia, which may be a prognostic indicator and
determinant of malignant progression, metastatic development and chemoradio-resistance …