PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is currently
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …

PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is a key
regulatory element of the hypoxic response of cells. High protein levels have been linked to …

High levels of hypoxia inducible factor (HIF)-1α in tumors are reported to be associated with
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …

Abstract Objectives/Hypothesis Tumor hypoxia appears to be closely associated with tumor
propagation, malignant progression, and resistance to radiotherapy. Hypoxia inducible …

Hypoxia-inducible factor-1α (HIF-1α) is both a potential endogenous marker of tumor
hypoxia and therapeutic target, and elevated HIF-1α protein levels have been shown to be …

Hypoxia has long been recognized as detrimental to the successful treatment of malignant
tumors with ionizing radiation. Because hypoxia-inducible factor (HIF)-1α plays an essential …

Tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by
increasing the expression of genes encoding angiogenic, metabolic and metastatic factors …

Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response
to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear …

BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …

Solid tumours contain regions of hypoxia, which may be a prognostic indicator and
determinant of malignant progression, metastatic development and chemoradio-resistance …