High-versatility left ventricle pump and aortic mock circulatory loop development for patient-specific hemodynamic in vitro analysis

E Vignali, E Gasparotti, A Mariotti, D Haxhiademi… - ASAIO …, 2022 - journals.lww.com
The importance of experimental setups able to reproduce cardiac functions was well
established in the field of clinical innovations. The mock circulatory loops acquired rising …

Development and validation of a life-sized mock circulatory loop of the human circulation for fluid-mechanical studies

J Gehron, J Zirbes, M Bongert, S Schäfer… - Asaio …, 2019 - journals.lww.com
Mock circulatory loops (MCLs) are usually developed for assessment of ventricular assist
devices and consist of abstracted anatomical structures represented by connecting tubing …

A novel passive left heart platform for device testing and research

AM Leopaldi, R Vismara, S Van Tuijl, A Redaelli… - Medical engineering & …, 2015 - Elsevier
Integration of biological samples into in vitro mock loops is fundamental to simulate real
device's operating conditions. We developed an in vitro platform capable of simulating the …

Design, simulation, and fabrication of a three-dimensional printed pump mimicking the left ventricle motion

E Vignali, Z Manigrasso, E Gasparotti… - … journal of artificial …, 2019 - journals.sagepub.com
The development of accurate replicas of the circulatory and cardiac system is fundamental
for a deeper understanding of cardiovascular diseases and the testing of new devices …

Design of an in vitro mock circulatory loop to reproduce patient-specific vascular conditions: Toward precision medicine

G Franzetti, V Díaz-Zuccarini… - … and Science in …, 2019 - asmedigitalcollection.asme.org
Patient-specific hemodynamic studies have attracted considerable attention in recent years
due to their potential to improve diagnosis and optimize clinical treatment of cardiovascular …

A compact mock circulation loop for the in vitro testing of cardiovascular devices

DL Timms, SD Gregory, NA Greatrex… - Artificial …, 2011 - Wiley Online Library
In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a
necessary step prior to in vivo testing. A MCL that accurately represents the physiology of …

Use of a mechanical circulatory support simulation to study pump interactions with the variable hemodynamic environment

DJ Horvath, DW Horvath, JH Karimov, N Byram… - Artificial …, 2018 - Wiley Online Library
Abstract The Virtual Mock Loop, a versatile virtual mock circulation loop, was developed
using a lumped‐parameter model of the mechanically assisted human circulatory system …

Development of a circulatory mock loop for biventricular device testing with various heart conditions

Y Kado, T Miyamoto, DJ Horvath… - … Journal of Artificial …, 2020 - journals.sagepub.com
This study aimed to evaluate a newly designed circulatory mock loop intended to model
cardiac and circulatory hemodynamics for mechanical circulatory support device testing. The …

A systemic mock circulation for in-vitro testing of a pneumatically operated left ventricular assist device

A Karabegovic, M Hinteregger, C Janeczek… - IFAC Proceedings …, 2014 - Elsevier
This work presents the development of a systemic mock circulation loop designed for testing
of an axial flow, pneumatically operated left ventricular assist device (LVAD). A simulation of …

A fast building and effective hydraulic pediatric mock circulatory system for the evaluation of a left ventricular assist device

F Huang, X Ruan, J Zou, W Qian, X Fu - ASAIO journal, 2013 - journals.lww.com
A mock circulatory system (MCS) has been proven a useful tool in the development of a
ventricular assist device. Nowadays a MCS aimed at the evaluation of pediatric blood …