Background: The authors have recently described that intrathecal IgM synthesis (ITMS)
correlates with a higher disability in patients with clinically definite MS (CDMS). Objective: To …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

The authors studied the intrathecal IgM synthesis (ITMS) in paired sera and CSF samples
from 65 patients with MS, 28 with CNS infection, 40 with other neurologic diseases and eight …

The objective of this study was to investigate, whether the presence of oligoclonal
immunoglobulin M bands (IgM‐OCB) in cerebrospinal fluid (CSF) from patients with a …

Background: Intrathecal IgM synthesis is reported to be associated with a worse prognosis in
adults with multiple sclerosis (MS). Objective: To study the predictive value of intrathecal IgM …

The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple
sclerosis, was found to correlate with the degree of disability (as evaluated by means of the …

Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …

Background: Previous studies have demonstrated that intrathecal synthesis of IgM is
observed in multiple sclerosis (MS) and correlates with a worse disease course. These …

Importance Reliable biomarkers associated with disability worsening in multiple sclerosis
(MS) are still needed. Objective To determine a possible association of intrathecal IgG …

Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …