Background Lentiviral vectors allow gene transfer into non‐dividing cells. Further
development of these vector systems requires stable packaging cell lines that enable …

We have successfully generated and characterized a stable packaging cell line for HIV-1-
based vectors. To allow safe production of vector, a minimal packaging construct carrying …

Lentiviral vectors are attractive candidates for gene therapy because of their ability to
integrate into nondividing cells. To date, conventional HIV-1-based vectors can be produced …

In contrast to oncoviruses, lentiviruses do not require target cell division for integration into
the host genome. Lentiviral vectors can therefore expand the spectrum of target cells …

The development of highly efficient and safe gene transfer methods suitable for clinical use
is required for human gene therapies. We have developed a novel lentiviral vector system …

Lentivirus-derived vectors are very promising gene delivery systems since they are able to
transduce nonproliferating differentiated cells, while murine leukemia virus-based vectors …

Background Human gene therapy vectors based on primate lentiviruses harbour in contrast
to oncoretroviruses the risk of vector mobilization by human immunodeficiency viruses (HIV) …

Lentiviral vectors (LVs) provide a powerful tool for gene transfer into both dividing and non-
dividing cells (for a review see Vigna and Naldini 1). They are able to stably transduce …

Heterologous lentiviral vectors (LVs) represent a way to address safety concerns in the field
of gene therapy by decreasing the possibility of genetic recombination between vector and …

We describe the generation and the characterization of new lentiviral vectors derived from
SIVmac251, a simian immunodeficiency virus (SIV). A methodical approach was used to …