[HTML][HTML] Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications

D Zhou, P Lu, X Mo, B Yang, T Chen, Y Yao… - Frontiers in …, 2024 - frontiersin.org
Metabolic syndrome is a medical condition characterized by several metabolic disorders in
the body. Long-term metabolic disorders raise the risk of cardiovascular disease (CVD) and …

Research Progress of Ferroptosis in Adiposity‐Based Chronic Disease (ABCD)

H Du, X Ren, J Bai, W Yang, Y Gao… - Oxidative Medicine and …, 2022 - Wiley Online Library
Ferroptosis is a multistep regulated cell death process induced by iron accumulation and
lipid peroxidation. Classical GPX4‐dependent pathway and GPX4‐independent pathways …

Ferroptotic cell death: new regulatory mechanisms for metabolic diseases

Y Le, Z Zhang, C Wang, D Lu - Endocrine, Metabolic & Immune …, 2021 - ingentaconnect.com
Background: Cell death is a fundamental biological phenomenon that contributes to the
pathogenesis of various diseases. Regulation of iron and iron metabolism has received …

[HTML][HTML] Ferroptosis and its potential role in metabolic diseases: a curse or revitalization?

JY Duan, X Lin, F Xu, SK Shan, B Guo… - Frontiers in Cell and …, 2021 - frontiersin.org
Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed
to the accumulation of lipid hydroperoxides and redox imbalance. In recent years …

The role of ferroptosis in metabolic diseases

L Xie, B Fang, C Zhang - Biochimica et Biophysica Acta (BBA)-molecular …, 2023 - Elsevier
The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver
disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy …

Narrative review of ferroptosis in obesity

LP He, ZX Zhou, CP Li - Journal of Cellular and Molecular …, 2023 - Wiley Online Library
Obesity is widely recognized as a major global health problem caused by a chronic energy
imbalance resulting from a combination of excess caloric intake and insufficient energy …

[HTML][HTML] Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities

R Miao, X Fang, Y Zhang, J Wei, Y Zhang… - Cell Death & Disease, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

[HTML][HTML] Ferroptosis as a novel therapeutic target for diabetes and its complications

XD Yang, YY Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
The global diabetes epidemic and its complications are increasing, thereby posing a major
threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its …

[HTML][HTML] Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes

G Du, Q Zhang, X Huang, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Ferroptosis is an iron-dependent programmed cell death, which is different from apoptosis,
necrosis, and autophagy. Specifically, under the action of divalent iron or ester oxygenase …

Ferroptosis: mechanisms and role in diabetes mellitus and its complications

P Liu, Z Zhang, Y Cai, Z Li, Q Zhou, Q Chen - Ageing Research Reviews, 2024 - Elsevier
Diabetes mellitus (DM) and its complications are major diseases that affect human health
and pose a serious threat to global public health. Although the prevention and treatment of …