Newman et al 1 review the safety profile of atorvastatin in nearly 10,000 patients involved in
44 clinical trials. Most of these studies included placebo groups or groups treated with …

The review by Smith and Grundy (1) of the American College of Cardiology/American Heart
Association Cholesterol Treatment Guideline is helpful, but recommendations for statin …

The Statin Safety Assessment Conference of the National Lipid Association (NLA), reported
in this supplement to The American Journal of Cardiology, provides a comprehensive …

Starting Statins — Polling Results | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH The New England …

If statistics is a science of probability then Sir William Osler expressed the limitations of its
applications when he articulated “Medicine is a science of uncertainty and an art of …

Statins have been available in the United States since 1987, and yet 15 years later most
patients who have had atherosclerotic events and/or diabetes mellitus, or who are at high …

This article reviews the safety of statins, with emphasis on high-dose atorvastatin (80 mg),
the agent with the most efficacy data for clinical outcomes. Although elevated levels of …

This analysis assessed the safety of atorvastatin in the 10-to 80-mg dose range using
pooled data from 44 completed trials comprising 16,495 dyslipidemic patients treated with …

The first statin, lovastatin, was approved for commercial use in the United States almost 30
years ago on September 1, 1987. Since that time, tens of millions of individuals have been …

Meta-analyses of randomized trials of statin therapy have shown that low-ering low-density
lipoprotein cholesterol levels reduces the risk of occlusive vascular events and improves …