Hypoxia-inducible factor 1 (HIF-1) is controlled through stability regulation of its alpha
subunit, which is expressed under hypoxia but degraded under normoxia. Degradation of …

Hypoxia inducible factor-1 (HIF-1) is the master regulator of metabolic adaptation to hypoxia.
It is appreciated that HIF-1α accumulation is achieved under normoxic conditions by eg …

The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …

The activity of hypoxia-inducible factor 1 (HIF-1) is primarily determined by stability
regulation of its α subunit, which is stabilized under hypoxia but degraded during normoxia …

We have investigated inhibitory mechanisms of hypoxic activation of HIF-1α by nitric oxide
(NO). Using a Hep3B cell-derived cell line, HRE7 cells, we found that the inhibition of HIF-1α …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

HIF-1α is a normally labile proangiogenic transcription factor that is stabilized and activated
in hypoxia. Although the von Hippel Lindau (VHL) gene product, the ubiquitin ligase …

Hypoxia inducible factor 1 (HIF-1) senses and coordinates cellular responses towards
hypoxia. HIF-1 activity is primarily determined by stability regulation of its alpha subunit that …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha
subunit and a beta subunit, that controls cellular responses to hypoxia. HIF α contains two …