Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be
unable to prevent human immunodeficiency virus infection but may have a long-term benefit …

The prevention of HIV-1 by vaccination has proven to be a formidable task. In an ongoing
endeavor to end the HIV-1 pandemic, scientists seek vaccines that will elicit quantitatively …

Objective: To investigate the potential to induce additional cytotoxic T-lymphocyte (CTL)
immunity during chronic HIV-1 infection. Design: We selected infrequently targeted or …

Pharmacological reactivation of human immunodeficiency virus (HIV) expression from latent
proviruses coupled with fully suppressive antiretroviral therapy (ART) has been suggested …

The induction of HIV specific CD8+ T cell responses is an important goal of ongoing vaccine
efforts. Emerging data on the key features of CD8+ T cell responses that distinguish …

Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that
are not merely modulated by the level of virus but clearly distinguish patients with immune …

CD8 cytotoxic T lymphocyte (CTL) and CD4 T-helper lymphocyte (HTL) responses play
important roles in the containment of HIV and SIVThe appearance of CTL in the acute phase …

Dysfunctional immune activation accumulates during chronic viral infection and contributes
to disease pathogenesis. In HIV-1, immune activation is exacerbated by concurrent infection …

Activated CD4 T cells are a major target of HIV infection. Results from the STEP HIV vaccine
trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition …

Affordable therapeutic strategies that induce sustained control of human immunodeficiency
virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed …