Aging is characterized by a deterioration in the maintenance of homeostatic processes over
time, leading to functional decline and increased risk for disease and death. The aging …

In mammals, insulin signaling regulates glucose homeostasis and plays an essential role in
metabolism, organ growth, development, fertility, and lifespan. The defects in this signaling …

Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1
(GH/IGF-1) axis are associated with increased life-and healthspan across model organisms …

The groundbreaking discovery that lower levels of insulin/IGF-1 signaling (IIS) can induce
lifespan extension was reported 24 years ago in the nematode Caenorhabditis elegans. In …

Reduced function mutations in the insulin/IGF‐I signaling pathway increase maximal
lifespan and health span in many species. Calorie restriction (CR) decreases serum IGF‐1 …

Animal models are fundamentally important in our quest to understand the genetic,
epigenetic, and environmental factors that contribute to human aging. In comparison to …

One of the original hypotheses of organismal longevity posits that aging is the natural result
of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into …

Background The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation
and are dysregulated in neurons in Alzheimer's disease (AD). We previously showed …

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to
mammals. In some organisms, this has been associated with a decreased fat mass and …

Recent studies implicate similar proteins in the regulation of longevity in organisms ranging
from yeast to mice. Studies in yeast and worms suggest that inactivation of glucose or …