Here, we review three sets of key proteins and their corresponding downstream pathways
that have been linked to extending lifespan and promoting health span in a wide range of …

Mammals possess multiple insulin‐like growth factor (IGF) binding proteins (IGFBPs), and
related proteins, that modulate the activity of insulin/IGF signalling (IIS), a conserved …

According to the somatomedin model, growth hormone (GH)-dependent hepatic synthesis is
responsible for maintaining circulating insulin-like growth factor (IGF)-I levels. On the other …

Traditional Yiddish Proverb METABoLIC syndrome consists of metabolic defects associated
with increased risks of type 2 diabetes mellitus, cardiovascular diseases, prothrombotic and …

Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a
key role against cancer development and is also closely associated with organismal aging …

Caloric restriction, leanness and decreased activity of insulin/insulin‐like growth factor 1
(IGF‐1) receptor signaling are associated with increased longevity in a wide range of …

GH/insulin/IGF-1 signaling is a vital pathway eg in the regulation of protein synthesis and
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …

The insulin receptor substrates (IRSs) function in insulin signaling. Four members of the
family, IRS-1 through IRS-4, are known. Previously, mice with targeted disruption of the …

In the present study we have used hypopituitary Ames dwarf mice, which lack GH, prolactin
and TSH, to investigate the consequences of the deficiency of these hormones on glucose …

Caloric restriction and leanness have been shown to increase longevity in organisms
ranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in the aging …