Key proteins and pathways that regulate lifespan
H Pan, T Finkel - Journal of Biological Chemistry, 2017 - ASBMB
Here, we review three sets of key proteins and their corresponding downstream pathways
that have been linked to extending lifespan and promoting health span in a wide range of …
that have been linked to extending lifespan and promoting health span in a wide range of …
Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
N Alic, MP Hoddinott, G Vinti, L Partridge - Aging cell, 2011 - Wiley Online Library
Mammals possess multiple insulin‐like growth factor (IGF) binding proteins (IGFBPs), and
related proteins, that modulate the activity of insulin/IGF signalling (IIS), a conserved …
related proteins, that modulate the activity of insulin/IGF signalling (IIS), a conserved …
Insulin-like growth factor I: implications in aging
E Arvat, F Broglio, E Ghigo - Drugs & aging, 2000 - Springer
According to the somatomedin model, growth hormone (GH)-dependent hepatic synthesis is
responsible for maintaining circulating insulin-like growth factor (IGF)-I levels. On the other …
responsible for maintaining circulating insulin-like growth factor (IGF)-I levels. On the other …
Insulin resistance and aging: a cause or a protective response?
N Barzilai, L Ferrucci - Journals of Gerontology Series A …, 2012 - academic.oup.com
Traditional Yiddish Proverb METABoLIC syndrome consists of metabolic defects associated
with increased risks of type 2 diabetes mellitus, cardiovascular diseases, prothrombotic and …
with increased risks of type 2 diabetes mellitus, cardiovascular diseases, prothrombotic and …
Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence
D Tran, J Bergholz, H Zhang, H He, Y Wang… - Aging cell, 2014 - Wiley Online Library
Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a
key role against cancer development and is also closely associated with organismal aging …
key role against cancer development and is also closely associated with organismal aging …
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat‐specific insulin receptor knock‐out mice
M Katic, AR Kennedy, I Leykin, A Norris… - Aging cell, 2007 - Wiley Online Library
Caloric restriction, leanness and decreased activity of insulin/insulin‐like growth factor 1
(IGF‐1) receptor signaling are associated with increased longevity in a wide range of …
(IGF‐1) receptor signaling are associated with increased longevity in a wide range of …
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-κB signaling
A Salminen, K Kaarniranta - Cellular signalling, 2010 - Elsevier
GH/insulin/IGF-1 signaling is a vital pathway eg in the regulation of protein synthesis and
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …
Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
VR Fantin, Q Wang, GE Lienhard… - American Journal of …, 2000 - journals.physiology.org
The insulin receptor substrates (IRSs) function in insulin signaling. Four members of the
family, IRS-1 through IRS-4, are known. Previously, mice with targeted disruption of the …
family, IRS-1 through IRS-4, are known. Previously, mice with targeted disruption of the …
[PDF][PDF] Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
FP Dominici, S Hauck, DP Argentino… - Journal of …, 2002 - researchgate.net
In the present study we have used hypopituitary Ames dwarf mice, which lack GH, prolactin
and TSH, to investigate the consequences of the deficiency of these hormones on glucose …
and TSH, to investigate the consequences of the deficiency of these hormones on glucose …
Extended longevity and insulin signaling in adipose tissue
N Klöting, M Blüher - Experimental gerontology, 2005 - Elsevier
Caloric restriction and leanness have been shown to increase longevity in organisms
ranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in the aging …
ranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in the aging …