Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life
span and delay age-related diseases. To address the interaction of these two interventions …

Reduced insulin-like signaling extends the life span of Caenorhabditis elegans and
Drosophila. Here, we show that, in mice, less insulin receptor substrate–2 (Irs2) signaling …

Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust
interventions known to increase longevity in lower organisms. However, little is known about …

Disruptions in growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling have been
linked to improved longevity in mice and humans. Nevertheless, while IGF-1 levels are …

Organ weight was compared in adult mice with deletion of one (IRS-1−/+) or both (IRS-1−/−)
copies of the insulin receptor substrate-1 (IRS-1) gene and IRS-1+/+ littermates. IRS-1−/+ …

Nutrient signaling through insulin/IGF-1 was the first pathway demonstrated to regulate
ageing and age-related disease in model organisms. Pharmacological or dietary …

Research into the biology of aging seeks to understand the basic mechanisms of aging, with
the goal of extending the period of life spent free from chronic disease and disability. Aging …

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia
are important factors both in aging and in the development of cancer. Insulin/insulin-like …

There is now an impressive body of literature implicating insulin and insulin signaling in
successful aging and longevity. New information from in vivo and in vitro studies concerning …

Aging is a global decline of physiological functions, leading to an increased susceptibility to
diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian …