We previously demonstrated that insulin receptor substrate 2 (Irs2) KO mice develop
diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia …

Aging is a global decline of physiological functions, leading to an increased susceptibility to
diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian …

Centenarians' offspring represent a suitable model to study age-dependent variables (eg
IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was …

While the growth hormone/insulin-like growth factor-1 (GH/IGF-1) pathway plays essential
roles in growth and development, diminished signaling via this pathway in model organisms …

Since 1996, seven genetic mouse models have been reported to show increased lifespan:
Ames and Snell dwarf mice, the 'little mouse'(Ghrhrlit/lit), mice null for either growth hormone …

Recent studies have demonstrated a significant association between mutations in genes
involved in the insulin/IGF1 signaling pathway and extension of the life span of model …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Alzheimer's disease (AD) is characterized by progressive neurodegeneration leading to loss
of cognitive abilities and ultimately to death. Postmortem investigations revealed decreased …

Studies of the effects of single-gene mutations on longevity in Caenorhabditis elegans,
Drosophila melanogaster and Mus musculus identified homologous, highly conserved …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …