Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction
KA Al-Regaiey, MM Masternak, M Bonkowski… - …, 2005 - academic.oup.com
Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life
span and delay age-related diseases. To address the interaction of these two interventions …
span and delay age-related diseases. To address the interaction of these two interventions …
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
A Satoh, CS Brace, N Rensing, P Cliften, DF Wozniak… - Cell metabolism, 2013 - cell.com
Summary The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
Current concepts regarding the biology of aging are primarily based on studies aimed at
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …
Coming of age: molecular drivers of aging and therapeutic opportunities
CB Newgard, NE Sharpless - The Journal of clinical …, 2013 - Am Soc Clin Investig
Aging is like the weather: everyone talks about it, but no one seems to do anything about it.
We believe this may soon change, as an improved understanding of the molecular and …
We believe this may soon change, as an improved understanding of the molecular and …
Interventions to slow aging in humans: are we ready?
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …
At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways
GP Fadini, G Ceolotto, E Pagnin… - Aging cell, 2011 - Wiley Online Library
The metabolic syndrome is becoming increasingly prevalent in the general population and
carries significant incremental morbidity and mortality. It is associated with multi‐organ …
carries significant incremental morbidity and mortality. It is associated with multi‐organ …
The somatotropic axis and longevity in mice
HM Brown-Borg - American Journal of Physiology …, 2015 - journals.physiology.org
The somatotropic signaling pathway has been implicated in aging and longevity studies in
mice and other species. The physiology and lifespans of a variety of mutant mice, both …
mice and other species. The physiology and lifespans of a variety of mutant mice, both …
Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats
CR Carvalho, SL Brenelli, AC Silva, AL Nunes… - …, 1996 - academic.oup.com
Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation
of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which, in turn, associates with …
of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which, in turn, associates with …
A conserved regulatory system for aging
C Kenyon - Cell, 2001 - cell.com
While many processes in biology, such as cell differentiso normal makes one optimistic that
if this system exists ation and development, increase complexity, the aging in humans, then …
if this system exists ation and development, increase complexity, the aging in humans, then …
Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
DJ Withers, DJ Burks, HH Towery, SL Altamuro… - Nature …, 1999 - nature.com
Insulin receptor substrates (Irs proteins) mediate the pleiotropic effects of insulin and Igf-1
(insulin-like growth factor-1), including regulation of glucose homeostasis and cell growth …
(insulin-like growth factor-1), including regulation of glucose homeostasis and cell growth …