Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life
span and delay age-related diseases. To address the interaction of these two interventions …

Summary The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …

Current concepts regarding the biology of aging are primarily based on studies aimed at
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …

Aging is like the weather: everyone talks about it, but no one seems to do anything about it.
We believe this may soon change, as an improved understanding of the molecular and …

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

The metabolic syndrome is becoming increasingly prevalent in the general population and
carries significant incremental morbidity and mortality. It is associated with multi‐organ …

The somatotropic signaling pathway has been implicated in aging and longevity studies in
mice and other species. The physiology and lifespans of a variety of mutant mice, both …

Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation
of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which, in turn, associates with …

While many processes in biology, such as cell differentiso normal makes one optimistic that
if this system exists ation and development, increase complexity, the aging in humans, then …

Insulin receptor substrates (Irs proteins) mediate the pleiotropic effects of insulin and Igf-1
(insulin-like growth factor-1), including regulation of glucose homeostasis and cell growth …