The molecular link between obesity and β cell failure that causes diabetes is difficult to
establish. Here we show that a conditional knockout of insulin receptor substrate 2 (Irs2) in …

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia
are important factors both in aging and in the development of cancer. It is possible that the …

Of all the age-related declines, memory loss is one of the most devastating. While conditions
that increase longevity have been identified, the effects of these longevity-promoting factors …

The Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates
aging and longevity across a wide variety of organisms, including yeast, worms, and flies. In …

Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals
with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to …

The aging process is characterized by progressive accumulation of damaged biomolecules
in the endoplasmic reticulum, as result of increased oxidative stress accompanying cellular …

We determined the effects of maternal diet-induced obesity on offspring adipose tissue
insulin signalling and miRNA expression in the aetiology of insulin resistance in later life …

Insulin-like growth factor-1 (IGF-1) and insulin are known to prevent apoptosis. The signaling
network of IGF-1 and insulin occurs via multiple pathways involving different insulin receptor …

Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in
elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to …

Based on the phenotypes of knockout mice and cell lines, as well as pathway-specific
analysis, the insulin receptor substrates IRS-1, IRS-2, IRS-3, and IRS-4 have been shown to …