The placenta provides critical transport functions between the maternal and fetal circulations
during intrauterine development. Formation of this interface relies on coordinated …

Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

The diversity of placental structures in Eutherian mammals is such that drawing
generalizations from the definitive forms is problematic. There are always areas of reduced …

Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and
for this purpose they are remodelled into highly dilated vessels by the action of invading …

The placenta is a complex, transient organ associated with viviparity, which is located at the
interface of the dam and fetus during pregnancy. It is formed after attachment, or …

The placenta is essential for fetal growth because it promotes the delivery of nutrients and
oxygen from the maternal circulation. In mice, many gene mutations disrupt formation of the …

In addition to many other functions, the placenta is a source of a vast number of autocrine,
paracrine and endocrine factors. However, the spectrum of placental regulatory factors, their …

The placenta is an ephemeral but critical organ for the survival of all eutherian mammals
and marsupials. It is the primary messenger system between the mother and fetus, where …

During embryogenesis in all mammalian species the placenta is formed inside the uterus by
apposition or fusion of maternally and embryonically-derived tissues. Genetically, normal …

The placenta is a gender-specific transitory organ with the sole purpose of enabling the
growth and development of the fetus. It mediates the efficient transfer and exchange of …