Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease
J Gockley, KS Montgomery, WL Poehlman, JC Wiley… - Genome medicine, 2021 - Springer
Background Alzheimer's disease (AD) is an incurable neurodegenerative disease currently
affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying …
affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying …
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …
have identified loci that harbor risk variants for neurodegenerative diseases, including …
Genes and pathways underlying regional and cell type changes in Alzheimer's disease
Abstract Background Transcriptional studies suggest Alzheimer's disease (AD) involves
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease
Introduction Genome-wide association studies (GWAS) have successfully identified multiple
independent genetic loci that harbour variants associated with Alzheimer's disease, but the …
independent genetic loci that harbour variants associated with Alzheimer's disease, but the …
Late-onset Alzheimer disease risk variants mark brain regulatory loci
M Allen, M Kachadoorian, MM Carrasquillo… - Neurology …, 2015 - AAN Enterprises
Objective: To investigate the top late-onset Alzheimer disease (LOAD) risk loci detected or
confirmed by the International Genomics of Alzheimer's Project for association with brain …
confirmed by the International Genomics of Alzheimer's Project for association with brain …
Identifying candidate genes and drug targets for Alzheimer's disease by an integrative network approach using genetic and brain region-specific proteomic data
Genome-wide association studies (GWAS) have identified more than 75 genetic variants
associated with Alzheimer's disease (ad). However, how these variants function and impact …
associated with Alzheimer's disease (ad). However, how these variants function and impact …
Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure
Background Alzheimer's disease (AD) is characterized by neuronal loss and astrocytosis in
the cerebral cortex. However, the specific effects that pathological mutations and coding …
the cerebral cortex. However, the specific effects that pathological mutations and coding …
Understanding Alzheimer disease at the interface between genetics and transcriptomics
J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …
common neurodegenerative dementia. However, mechanistic insights and improved …