Maternal aging results in reduced oocyte and blastocyst quality, thought to be due, in part, to
mitochondrial dysfunction and accumulation of reactive oxygen species. To reduce oxidative …

STUDY QUESTION What is the effect of three antioxidants (acetyl-L-carnitine, N-acetyl-L-
cysteine and α-lipoic acid), when used individually and in combination, on mouse embryo …

STUDY QUESTION Can we use a mitochondrial-targeted antioxidant (Mitoquinone) during
in vitro embryo culture to rescue developmental competence of oocytes matured under …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

OBJECTIVE: Increased maternal age is accompanied by changes in metabolic activity of
oocytes. As mitochondria are exclusively maternally inherited, alterations in their activity may …

The objective of this study was to test whether aging induces oxidative stress (OS) during
oocyte preservation at different temperatures and whether the oocyte competence can be …

STUDY QUESTION Does in vivo aging of mouse oocytes affect mitochondrial function?
SUMMARY ANSWER Mitochondrial function was impaired in post-ovulatory in vivo-aged …

In this study, using a mouse model, we tested the hypothesis that restraint stress would
impair the developmental potential of oocytes by causing oxidative stress and that …

Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of
reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly …