Sepsis and multiple organ failure continue to be significant problems among trauma, burn,
and the critically ill patient population. Thus, a number of laboratories have focused on …

Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

The inability of present therapies to mitigate the devastating effects of sepsis and multiple
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …

Patients with sepsis have impaired host defenses that contribute to the lethality of the
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

Sepsis with subsequent multiple-organ dysfunction is a distinct systemic inflammatory
response to concealed or obvious infection, and it is a leading cause of death in intensive …

Patients with sepsis are immune compromised, as evidenced by their failure to clear their
primary infection and their propensity to develop secondary infections with pathogens that …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …