Cell migration through solid tissue often involves large contortions of the nucleus, but
biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both …

Cell motility plays a critical role in many physiological and pathological settings, ranging
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human
diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

The ability of a cell to regulate its mechanical properties is central to its function. Emerging
evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell …

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …

Nuclear lamins play central roles at the intersection between cytoplasmic signalling and
nuclear events. Here, we show that at least two N-and C-terminal lamin epitopes are not …

Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that
lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …