We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …

Two independent epigenome-wide association studies of Alzheimer's disease cohorts have
identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23 …

Importance Recent large-scale genome-wide association studies have discovered several
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA …

Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …

Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …

Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset
Alzheimer's disease (LOAD), but little has been done on a genome-wide scale to identify …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …

Recent epigenome-wide association studies in Alzheimer's disease have highlighted
consistent robust neuropathology-associated DNA hypermethylation of the ankyrin 1 (ANK1) …