Tumor mutation burden-assisted risk stratification for papillary thyroid cancer

Z Chen, W Wang, J Xu, Y Song, H Zhu, T Ma, M Ge… - Endocrine, 2022 - Springer
Purpose Although papillary thyroid cancer (PTC) has a low mortality rate, the rate of
recurrence remains relatively high. This study aims to develop a molecular signature to …

The predictive value of coexisting BRAFV600E and TERT promoter mutations on poor outcomes and high tumour aggressiveness in papillary thyroid carcinoma: A …

B Chen, Y Shi, Y Xu, J Zhang - Clinical endocrinology, 2021 - Wiley Online Library
BRAFV600E mutation is highly prevalent in patients with papillary thyroid carcinoma (PTC),
and TERT promoter (TERTp) mutation is strongly associated with cancer‐related mortality …

Impact of BRAF V600E and TERT Promoter Mutations on Response to Therapy in Papillary Thyroid Cancer

T Trybek, A Walczyk, D Gąsior-Perczak, I Pałyga… - …, 2019 - academic.oup.com
In this study, we examined the relationship between coexisting BRAF V600E and TERT
promoter mutations in papillary thyroid cancer (PTC) and response to therapy. PTC cases …

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence

M Xing, R Liu, X Liu, AK Murugan, G Zhu… - Journal of clinical …, 2014 - ascopubs.org
Purpose To investigate the prognostic value of the BRAF V600E mutation and the recently
identified TERT promoter mutation chr5: 1,295,228 C> T (C228T), individually and in their …

Effects of Coexistent BRAFV600E and TERT Promoter Mutations on Poor Clinical Outcomes in Papillary Thyroid Cancer: A Meta-Analysis

S Moon, YS Song, YA Kim, JA Lim, SW Cho, JH Moon… - Thyroid, 2017 - liebertpub.com
Background: The presence of a telomerase reverse transcriptase (TERT) promoter mutation
has been suggested as a potential prognostic marker for thyroid cancer, and a synergistic …

Prognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—a meta‐analysis

HG Vuong, AMA Altibi, UNP Duong… - Clinical …, 2017 - Wiley Online Library
Introduction The use of molecular markers, especially BRAF and TERT promoter mutations,
for risk stratification in papillary thyroid carcinoma (PTC) is subject to continuing debate. In …

Genetic alterations and allele frequency of BRAF V600E and TERT mutation in papillary thyroid carcinoma with intermediate-to-high recurrence risk: a retrospective …

J Huang, J Wang, J Xv, J Wang, G Wang… - Clinical and Experimental …, 2024 - Springer
The predictive value of allele frequency (AF) of BRAF V600E and TERT mutations in
papillary thyroid carcinoma (PTC) remains controversial. We aimed to investigate the AF of …

A six-genotype genetic prognostic model for papillary thyroid cancer

X Shen, R Liu, M Xing - Endocrine-related cancer, 2017 - erc.bioscientifica.com
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations
in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation …

The coexistence of genetic mutations in thyroid carcinoma predicts histopathological factors associated with a poor prognosis: a systematic review and network meta …

L Zhao, L Wang, X Jia, X Hu, P Pang, S Zhao… - Frontiers in …, 2020 - frontiersin.org
Purpose Genetic mutations may play an important role in the progression and invasion of
thyroid carcinoma (TC), and their coexistence may result in mutational synergy. The …

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer

AJ Lin, P Samson, T DeWees, L Henke… - Cancer …, 2019 - Wiley Online Library
Background Prognosis among patients with differentiated thyroid cancer is widely variable.
Better understanding of biologic subtypes is necessary to stratify patients and improve …