Ataxin-1 is a neurodegenerative disorder protein whose mutant form causes spinocerebellar
ataxia type-1 (SCA1). Evidence suggests that ataxin-1 may function as a transcription …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant genetic disease
characterized by cerebellar dysfunction associated with slow saccades, early hyporeflexia …

Abstract Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by a
polyglutamine-encoding CAG repeat expansion in the ATXN3 gene. This expansion leads to …

Machado–Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative
disease caused by the expansion of a CAG tract in the coding portion of the ATXN3 gene …

Spinocerebellar ataxia (SCA) type 10, an autosomal dominant disease characterized by
cerebellar ataxia, is caused by a novel pentanucleotide (ATTCT) repeat expansion in the …

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative
disorder characterized by ataxia and progressive motor deterioration. SCA1 has been …

Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative
disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive
degeneration of cerebellar Purkinje cells (PCs) and other neurons caused by expansion of a …

As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3)
remain elusive, which limits our understanding of its normal cellular function and that of …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited,
neurodegenerative disease caused by an expansion of polyglutamine tracts in the cytosolic …