Ataxin‐1 is a neurodegenerative disorder protein whose glutamine‐repeat expanded form
causes spinocerebellar ataxia type 1 (SCA1) in humans and exerts cytotoxicity in Drosophila …

Polyglutamine (polyQ) diseases are caused by expansion of translated CAG repeats in
distinct genes leading to altered protein function. In spinocerebellar ataxia type 1 (SCA1), a …

Protein cleavage is a common feature in human neurodegenerative disease. Ataxin-3
protein with an expanded polyglutamine (polyQ) repeat causes spinocerebellar ataxia type …

Polyglutamine (polyQ) repeat expansion in the deubiquitinase ataxin-3 causes
neurodegeneration in Spinocerebellar Ataxia Type 3 (SCA3), one of nine inherited …

Glutamine tract expansion triggers nine neurodegenerative diseases by conferring toxic
properties to the mutant protein. In SCA1, phosphorylation of ATXN1 at Ser776 is thought to …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, is
responsible for spinocerebellar ataxia type 1. Requirements for developing the disease are …

Spinocerebellar ataxia type-3 or Machado-Joseph disease (SCA3/MJD) is a member of the
CAG/poly-glutamine repeat disease family. In this family of disorders, a normally …

Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3
gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein …

Polyglutamine (polyQ) expansion within the ataxin-7 protein, a member of the STAGA [SPT3-
TAF (II) 31-GCN5L acetylase] and TFTC (GCN5 and TRRAP) chromatin remodeling …