Abstract Purpose: Vinorelbine (Navelbine) is an orally absorbable Vinca with broad
antitumor activity. It differs from other Vinca in that it is structurally modified on the …

Abstract Background A Phase II trial was developed to determine the efficacy and toxicity of
intravenous vinorelbine, a semi‐synthetic vinca alkaloid, in children, adolescent, and young …

BACKGROUND Vinca alkaloids have proved active against a number of pediatric
malignancies. The aim of this study was to assess the feasibility and effectiveness of using …

PURPOSE The feasibility of administering vinorelbine (Navelbine, Burroughs Wellcome Co,
Research Triangle Park, NC), a semisynthetic vinca alkaloid with broad activity, as a liquid …

Vinorelbine (Navelbine') is a new, semisynthetic 5'Nor-vinca-alkaloid, modified on the
catharantine ring, developed by Pierre Fabre Medicament. Vinorelbine is as potent as the …

The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and
dosage and administration of vinorelbine are reviewed. Vinorelbine is a semisynthetic vinca …

Purpose: The activity of vinorellbine, a new semisynthetic vinca alkaloid, was evaluated
against a battery of human tumor xenografts derived from adult and pediatric CNS …

The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in
humans with a wide spectrum of activity against both animal and human tumors. These …

Background Patient preference as well as concerns and difficulties with intravenous access
and pharmaco-economic issues have driven the development of oral vinorelbine. Patients …

Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre
Médicament, Paris, France) is a semisynthetic vinca alkaloid agent that has been structurally …