Background Pharmacokinetics of vinorelbine is mainly known from studies conducted in
European patients. Interethnic differences in drug disposition may, however, induce …

Abstract The antitumor drug navelbine (5′-noranhydrovinblastine) was converted into a
reactive acid azide and covalently coupled to free amino groups of bovine serum albumin …

To evaluate the effectiveness of vinorelbine (NVB) in patients with non-small cell lung
cancer (NSCLC), a late Phase II study was conducted. A total of 80 patients with Stage III or …

Aims There is a crucial need for pharmacokinetic (PK) data on oral vinorelbine (VNR) in the
paediatric population. The aim of this work was to assess the PK profile of orally …

Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre
Médicament, Paris, France) is a novel semisynthetic vinca alkaloid with antitumor activity in …

Vindesine, a vinca alkaloid derived from vinblastine, has been examined for activity against
a variety of solid and hematological malignancies. Single-agent response rates average …

A large body of preclinical and clinical data concerning the new semisynthetic vinca alkaloid
vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre …

1. Vinorelbine (NVB), a new semi-synthetic vinca alkaloid, is currently used in the treatment
of advanced non-small-cell lung cancer (NSCLC) and advanced breast cancer. The …

The effects of food and divided dosing on the bioavailability of a liquid-filled gelatin capsule
formulation of vinorelbine (Navelbine), a semisynthetic vinca alkaloid with broad clinical …

The development of an oral formulation of vinorelbine (Navelbine softgelatine capsules,
Pierre Fabre Pharma, Freiburg i. Br., Germany) represents a significant advance in the …