Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life-threatening
condition of critically-ill patients, characterized by overwhelming inflammatory responses in …

Gold nanoparticles (GNPs) have shown great promises in various biomedical applications.
Although GNPs exhibit excellent therapeutic efficacy in in vitro and in vivo in numerous …

Overwhelming uncontrolled inflammation is the hallmark of pathophysiological features of
many acute and chronic inflammatory diseases, such as sepsis and allergy and autoimmune …

Background Macrophage polarization and reprogramming in the lung play a critical role in
the initiation, development and progression of acute lung injury (ALI). Regulating the …

Toll‐like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of
acute lung injury (ALI). While TLR inhibition is a promising strategy to control the …

Toll-like receptor (TLR) signaling plays a central role in the pathophysiology of many acute
and chronic human inflammatory diseases, and pharmacological regulation of TLR …

Manipulation of immune responsiveness using nanodevices provides a potential approach
to treat human diseases. Toll-like receptor (TLR) signaling plays a central role in the …

Background Uncontrolled inflammation is a central problem for many respiratory diseases.
The development of potent, targeted anti-inflammatory therapies to reduce lung …

The ability of nanoparticle surface functionalities to regulate immune responses during an
immunological challenge (ie, inflammation) would open new doors for their use in non …

Endotoxicity originating from a dangerous debris (ie, lipopolysaccharide, LPS) of Gram-
negative bacteria is a challenging clinical problem, but no drugs or therapeutic strategies …