Exosomes are membrane-enriched extracellular vesicles with a proposed diameter in the
range of 30–100 nm. They are released during both normal homeostasis as well as under …

Introduction The hunt for new biomarkers–for the diagnosis of subcategories of disease, or
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …

Alzheimer's disease (AD) and Parkinson's disease (PD) are incurable, devastating
neurodegenerative disorders characterized by the formation and spreading of protein …

Intercellular communication between neurons and their surrounding cells occurs through the
secretion of soluble molecules or release of vesicles such as exosomes into the extracellular …

Exosomes are small membranous entities of endocytic origin. Their production by a wide
variety of cells in eukaryotes implicates their roles in the execution of essential processes …

Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease
(AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts …

Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane
vesicles secreted by almost all cell types and are abundant in blood, body fluids, such as …

The pathogenesis of amyotrophic lateral sclerosis (ALS), a lethal neurodegenerative
disease, remains undisclosed. Mutations in ALS related genes have been identified, albeit …

To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …

Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles
(EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins …