Extracellular vesicles (EVs) shed by neurons and glia in the central nervous system carry a
cargo of specific bioactive molecules, facilitating intercellular communication. However, in …

Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare
systems and serves as a leading cause of disability and death. Alzheimer's disease (AD) is …

Extracellular vesicles (EVs) are gaining increased importance in fundamental research as
key players in disease pathogenic mechanisms, but also in translational and clinical …

Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest
in the role of central nervous system (CNS)-derived EVs has been increasing; however …

Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of
biological macromolecules. In recent years, the functions of exosomes in the spreading of …

Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may
represent a new biosignaling paradigm. According to the mode of biogenesis, size and …

Homeostasis relies heavily on effective cell-to-cell communication. In the central nervous
system (CNS), probably more so than in other organs, such communication is crucial to …

Shedding of nano-sized bilayered extracellular vesicles and extracellular vesicle-mediated
intercellular communication are evolutionarily conserved biological processes …

Brain disorders are the leading cause of disability worldwide, affecting people's quality of life
and causing economic burdens. The current clinical diagnosis of brain disorders relies …

Neuroinflammation is a common pathological feature of amyotrophic lateral sclerosis (ALS).
Although scientific evidence to date does not allow defining neuroinflammation as an ALS …