Role of exosomes in central nervous system diseases

W Liu, X Bai, A Zhang, J Huang, S Xu… - Frontiers in molecular …, 2019 - frontiersin.org
There are many types of intercellular communication, and extracellular vesicles are one of
the important forms of this. They are released by a variety of cell types, are heterogeneous …

[HTML][HTML] Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders

S Zhao, S Sheng, Y Wang, L Ding, X Xu, X Xia… - Neuroscience & …, 2021 - Elsevier
Recent studies suggest that astrocytes released a great quantity of EVs (AEVs) to
communicate with other brain cells. Under pathological conditions, AEVs are widely …

Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid

K Otake, H Kamiguchi, Y Hirozane - BMC medical genomics, 2019 - Springer
Background Exosomes are a subset of extracellular vesicles 30–200 nm in diameter
secreted from cells, which contain functional mRNAs and microRNAs. Cerebrospinal fluid …

Transcriptome of extracellular vesicles: state-of-the-art

A Turchinovich, O Drapkina, A Tonevitsky - Frontiers in immunology, 2019 - frontiersin.org
Exosomes and microvesicles are two major categories of extracellular vesicles (EVs)
released by almost all cell types and are highly abundant in biological fluids. Both the …

Role of exosomes in brain diseases

N Zhang, F He, T Li, J Chen, L Jiang… - Frontiers in Cellular …, 2021 - frontiersin.org
Exosomes are a subset of extracellular vesicles that act as messengers to facilitate
communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are …

Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Saliva and Saliva extracellular vesicles for biomarker candidate Identification—assay development and pilot study in amyotrophic lateral sclerosis

S Sjoqvist, K Otake - International Journal of Molecular Sciences, 2023 - mdpi.com
Saliva is gaining increasing attention as a source of biomarkers due to non-invasive and
undemanding collection access. Extracellular vesicles (EVs) are nano-sized, cell-released …

Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Endo-lysosomal dysfunction in neurodegenerative diseases: Opinion on current progress and future direction in the use of exosomes as biomarkers

M Herman, GW Randall, JL Spiegel… - … of the Royal …, 2024 - royalsocietypublishing.org
Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …

CNS-derived blood exosomes as a promising source of biomarkers: opportunities and challenges

S Hornung, S Dutta, G Bitan - Frontiers in Molecular Neuroscience, 2020 - frontiersin.org
Eukaryotic cells release different types of extracellular vesicles (EVs) including exosomes,
ectosomes, and microvesicles. Exosomes are nanovesicles, 30–200 nm in diameter, that …