Surface Proteins of Staphylococcus aureus

TJ Foster - Microbiology spectrum, 2019 - Am Soc Microbiol
The surface of Staphylococcus aureus is decorated with over 20 proteins that are covalently
anchored to peptidoglycan by the action of sortase A. These cell wall-anchored (CWA) …

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

TJ Foster, JA Geoghegan, VK Ganesh… - Nature reviews …, 2014 - nature.com
Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes
about 20% of the human population. Its surface is' decorated'with proteins that are covalently …

Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions

JA Geoghegan, TJ Foster - Staphylococcus aureus: Microbiology …, 2017 - Springer
Staphylococcus aureus persistently colonizes about 20% of the population and is
intermittently associated with the remainder. The organism can cause superficial skin …

The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens

KA Lacey, JA Geoghegan, RM McLoughlin - Pathogens, 2016 - mdpi.com
Staphylococcus aureus (S. aureus) causes the vast majority of skin and soft tissue infections
(SSTIs) in humans. S. aureus has become increasingly resistant to antibiotics and there is …

Anchor structure of staphylococcal surface proteins: a branched peptide that links the carboxyl terminus of proteins to the cell wall

H Ton-That, KF Faull, O Schneewind - Journal of biological chemistry, 1997 - ASBMB
Surface proteins of Staphylococcus aureus are anchored to the cell wall by a mechanism
requiring a COOH-terminal sorting signal. Previous work demonstrated that the sorting …

Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus

A DeDent, T Bae, DM Missiakas… - The EMBO journal, 2008 - embopress.org
Surface proteins of Gram‐positive bacteria are covalently linked to the cell wall envelope by
a mechanism requiring an N‐terminal signal peptide and a C‐terminal LPXTG motif sorting …

Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall

SK Mazmanian, G Liu, H Ton-That, O Schneewind - Science, 1999 - science.org
Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a
mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that …

Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

SK Mazmanian, G Liu, ER Jensen… - Proceedings of the …, 2000 - National Acad Sciences
Many Gram-positive bacteria covalently tether their surface adhesins to the cell wall
peptidoglycan. We find that surface proteins of Staphylococcus aureus are linked to the cell …

Surface protein adhesins of Staphylococcus aureus

TJ Foster, M Höök - Trends in microbiology, 1998 - cell.com
Staphylococcus aureus can colonize the host to initiate infection by adhering to components
of the extracellular matrix. Adherence is mediated by surface protein adhesins …

Anchoring of surface proteins to the cell wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2 …

H Ton-That, SK Mazmanian, KF Faull… - Journal of Biological …, 2000 - ASBMB
Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by
cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan …