Animal models in epileptic spasms and the development of novel treatment options

KT Barrett, A Choudhary, B Charkhand… - Journal of Clinical …, 2022 - journals.lww.com
The infantile spasms (IS) syndrome is a catastrophic developmental epileptic
encephalopathy syndrome characterized by an age-specific expression of epileptic spasms …

[HTML][HTML] Infantile spasms: an update on pre-clinical models and EEG mechanisms

R Janicot, LR Shao, CE Stafstrom - Children, 2020 - mdpi.com
Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic
features, which affects children in the middle of the first year of life. The pathophysiology of …

[HTML][HTML] On the basic mechanisms of infantile spasms

JW Swann, SL Moshe - 2012 - europepmc.org
Infantile spasms is an unusual seizure disorder. The seizures themselves are only a few
seconds in duration and consist of brief flexion and/or extension jerking movements. EEG …

Mechanisms of infantile epileptic spasms syndrome: What have we learned from animal models?

ACH Ng, A Choudhary, KT Barrett, C Gavrilovici… - …, 2024 - Wiley Online Library
The devastating developmental and epileptic encephalopathy of infantile epileptic spasms
syndrome (IESS) has numerous causes, including, but not limited to, brain injury, metabolic …

Animal models of infantile spasms: focus on new treatments

J Velíšková, L Velíšek - Handbook of Animal Models in Neurological …, 2023 - Elsevier
Infantile spasms (IS) represent a severe encephalopathy of infancy, which is a result of
multiple etiologies. IS are characterized by intractable spastic seizures, EEG …

Utilizing animal models of infantile spasms

CG Dulla - Epilepsy Currents, 2018 - journals.sagepub.com
Infantile spasms are a devastating epileptic encephalopathy characterized by early life
spasms and later seizures. Clinical outcomes of infantile spasms are poor and therapeutic …

Modeling epileptic spasms during infancy: Are we heading for the treatment yet?

L Velíšek, J Velíšková - Pharmacology & therapeutics, 2020 - Elsevier
Infantile spasms (IS or epileptic spasms during infancy) were first described by Dr. William
James West (aka West syndrome) in his own son in 1841. While rare by definition (occurring …

Infantile spasms: criteria for an animal model

CE Stafstrom, GL Holmes - International review of neurobiology, 2002 - Elsevier
Infantile spasms is an epilepsy syndrome with several distinctive features, including age
specificity during infancy, characteristic semiology (epileptic spasms), specific …

A model of symptomatic infantile spasms syndrome

MH Scantlebury, AS Galanopoulou… - Neurobiology of …, 2010 - Elsevier
Infantile spasms are characterized by age-specific expression of epileptic spasms and
hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or …

Developing an animal model for infantile spasms: pathogenesis, problems and progress

ED Marsh, JA Golden - Disease Models & Mechanisms, 2009 - journals.biologists.com
Infantile spasms (IS), the most common of the early epileptic encephalopathies, afflicts
thousands of children each year and results in significant disability. Also known as West …