Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug

A Oberholzer, C Oberholzer, LL Moldawer - Critical care medicine, 2002 - journals.lww.com
Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock

J Gomez-Jimenez, MC Martin, R Sauri… - Journal of Infectious …, 1995 - academic.oup.com
Abstract Interleukin (IL)-10 is a potent immunosuppressant of monocyte/macrophage
function and may help control the inflammatory response induced by bacterial infection. To …

Therapeutic implications of interleukin-10 in surgical disease

CH Selzman, BD Shames, SA Miller, EJ Pulido… - Shock, 1998 - journals.lww.com
Pharmacological therapy of surgical disease often involves manipulating the physiologic
balance between pro-and anti-inflammatory responses. Many agents target only one aspect …

Interleukin 10 reduces mortality from severe peritonitis in mice

T Kato, A Murata, H Ishida, H Toda… - Antimicrobial agents …, 1995 - Am Soc Microbiol
Interleukin 10 (IL-10) is known to suppress the induction of proinflammatory cytokines such
as tumor necrosis factor (TNF) and IL-1 and is itself induced by monocytes and …

What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?

GY Song, CS Chung, IH Chaudry, A Ayala - Surgery, 1999 - Elsevier
Background: Controversy exists concerning the role of interleukin 10 (IL-10) in sepsis. When
IL-10 is used in models of endotoxemia, it appears to protect (by anti-inflammatory effects) …

Interleukin-10: potential benefits and possible risks in clinical infectious diseases

SM Opal, JC Wherry, P Grint - Clinical infectious diseases, 1998 - academic.oup.com
Abstract Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the
synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2 …

Interleukin 10 protects mice from lethal endotoxemia.

M Howard, T Muchamuel, S Andrade… - The Journal of …, 1993 - rupress.org
Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha
(TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same …

Blood interleukin 10 levels parallel the severity of septic shock

G Friedman, S Jankowski, A Marchant, M Goldman… - Journal of critical …, 1997 - Elsevier
Purpose: The aim of this study was to investigate the relation between interleukin (IL) 10,
tumor necrosis factor alpha (TNFα), IL-1, and IL-6 levels in patients with septic shock and …

Interleukin-18: a novel prognostic cytokine in bacteria-induced sepsis

SK Tschoeke, A Oberholzer, LL Moldawer - Critical care medicine, 2006 - journals.lww.com
Objective: Severe inflammation and sepsis remain a serious clinical challenge worldwide.
Despite modern supportive medicine and an improved understanding of the underlying …

Interleukin-8 in sepsis: relation to shock and inflammatory mediators

CE Hack, M Hart, RJ Van Schijndel… - Infection and …, 1992 - Am Soc Microbiol
Because of its neutrophil-activating properties, interleukin-8 (IL-8) may play an important
role in the pathophysiology of sepsis. We measured circulating IL-8 levels in 47 patients with …