Tunneling nanotubes: a new target for nanomedicine?

I Ottonelli, R Caraffi, G Tosi, MA Vandelli… - International Journal of …, 2022 - mdpi.com
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells
utilized for intercellular transfer and communication. These newly discovered structures …

Opportunities and challenges in tunneling nanotubes research: how far from clinical application?

X Han, X Wang - International journal of molecular sciences, 2021 - mdpi.com
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting
distance cells. In the last decade, growing evidence has shown that these subcellular …

Tunneling nanotubes: a versatile target for cancer therapy

P Sahu, SR Jena, L Samanta - Current Cancer Drug Targets, 2018 - ingentaconnect.com
Currently Cancer is the leading cause of death worldwide. Malignancy or cancer is a class of
diseases characterized by uncontrolled cell growth that eventually invade other tissues and …

Tunneling Nanotube: An Enticing Cell–Cell Communication in the Nervous System

S Dagar, S Subramaniam - Biology, 2023 - mdpi.com
Simple Summary This review highlights the role of tunneling nanotubes (TNTs) and TNT-like
structures in the nervous system. TNTs are thin, hollow plasma membrane projections that …

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

R Mittal, E Karhu, JS Wang, S Delgado… - Journal of cellular …, 2019 - Wiley Online Library
Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …

Peering into tunneling nanotubes—The path forward

D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …

Emerging physiological and pathological implications of tunneling nanotubes formation between cells

S Sisakhtnezhad, L Khosravi - European journal of cell biology, 2015 - Elsevier
Cell-to-cell communication is a critical requirement to coordinate behaviors of the cells in a
community and thereby achieve tissue homeostasis and conservation of the multicellular …

Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

PK Melwani, BN Pandey - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …

Intercellular communication in the brain through tunneling nanotubes

KE Khattar, J Safi, AM Rodriguez, ML Vignais - Cancers, 2022 - mdpi.com
Simple Summary Tunneling nanotubes (TNTs) are a means of cell communication which
have been recently discovered. They allow the intercellular trafficking of many types of …

Identification and characterization of tunneling nanotubes for intercellular trafficking

S Abounit, E Delage, C Zurzolo - Current protocols in cell …, 2015 - Wiley Online Library
Tunneling nanotubes (TNTs) are thin membranous channels providing direct cytoplasmic
connection between remote cells. They are commonly observed in different cell cultures and …