The stereoselective synthesis of sialosides is still one of the major challenges in
carbohydrate chemistry. The synthesis and glycosidation of novel sialyl donors bearing a …

A novel 8-O-picoloylated sialyl donor has been developed, and the performance of various
picoloylated sialyl donors in glycosylations with primary glycosyl acceptors has been …

In spite of notable achievements for the synthesis of α‐sialosides that have been made in
the past decades, sialylation reactions often require low temperatures (–40 to–78° C) and …

Chemical construction of a α-glycoside of sialic acid is a demanding subject due to the
structural disadvantages of sialic acid: the carboxylate group at C1, the deoxy moiety …

The profound effect of substituents at C-5 of glycosyl sialosides on their stereoselectivity is
well-known although the exact nature of this effect is somewhat less understood. Presented …

Although tremendous efforts have been made for the efficient preparation of sialosides,
controlling the stereochemical outcome of sialylation reaction still remains one of the most …

Sialic acids usually occur as glycosides of functional glycoconjugates such as
glycoprooteins and glycolips, that are involved in a wide range of biological phenomena, for …

Sialic acid is an important component of cell surface glycans, which are responsible for
many vital body functions and should therefore be thoroughly studied to understand their …

N-Acetyl neuraminic acid (Neu5Ac) is most frequently found at the terminal end of
glycoconjugates on the cell surface. This terminally exposed position allows Neu5Ac …

The synthesis of α‐sialosides is one of the most difficult reactions in carbohydrate chemistry
and is considered to be both a thermodynamically and kinetically disfavored process. The …