Overcoming poor oral bioavailability using nanoparticle formulations–opportunities and limitations
Oral delivery of drugs with poor aqueous solubility and poor enzymatic and/or metabolic
stability is very challenging. However, the advent of nanotechnology has revolutionized the …
stability is very challenging. However, the advent of nanotechnology has revolutionized the …
Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?
R Diab, C Jaafar-Maalej, H Fessi, P Maincent - The AAPS journal, 2012 - Springer
For the past few decades, there has been a considerable research interest in the area of oral
drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been …
drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been …
Influence of particle geometry on gastrointestinal transit and absorption following oral administration
D Li, J Zhuang, H He, S Jiang, A Banerjee… - … applied materials & …, 2017 - ACS Publications
Geometry has been considered as one of the important parameters in nanoparticle design
because it affects cellular uptake, transport across the physiological barriers, and in vivo …
because it affects cellular uptake, transport across the physiological barriers, and in vivo …
Nanoparticles in the clinic
AC Anselmo, S Mitragotri - Bioengineering & translational …, 2016 - Wiley Online Library
Nanoparticle/microparticle‐based drug delivery systems for systemic (ie, intravenous)
applications have significant advantages over their nonformulated and free drug …
applications have significant advantages over their nonformulated and free drug …
Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology
Mucosal tissues constitute the largest interface between the body and the surrounding
environment and they regulate the access of molecules, supramolecular structures …
environment and they regulate the access of molecules, supramolecular structures …
Facing the truth about nanotechnology in drug delivery
K Park - ACS nano, 2013 - ACS Publications
Nanotechnology in drug delivery has been manifested into nanoparticles that can have
unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors …
unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors …
Insight into nanoparticle cellular uptake and intracellular targeting
Collaborative efforts from the fields of biology, materials science, and engineering are
leading to exciting progress in the development of nanomedicines. Since the targets of many …
leading to exciting progress in the development of nanomedicines. Since the targets of many …
Targeted nanoparticles with novel non-peptidic ligands for oral delivery
A des Rieux, V Pourcelle, PD Cani… - Advanced drug delivery …, 2013 - Elsevier
Orally administered targeted nanoparticles have a large number of potential biomedical
applications and display several putative advantages for oral drug delivery, such as the …
applications and display several putative advantages for oral drug delivery, such as the …
Nanoparticles in the clinic: An update
AC Anselmo, S Mitragotri - Bioengineering & translational …, 2019 - Wiley Online Library
Nanoparticle drug delivery systems have been used in the clinic since the early 1990's.
Since that time, the field of nanomedicine has evolved alongside growing technological …
Since that time, the field of nanomedicine has evolved alongside growing technological …
Nanotherapeutics in oral and parenteral drug delivery: Key learnings and future outlooks as we think small
P Tyagi, JA Subramony - Journal of Controlled Release, 2018 - Elsevier
Nanotechnology ushered the field of medicine in to a new era. Miniaturization, increased
surface area, and the unique physicochemical properties in the nano dimension were …
surface area, and the unique physicochemical properties in the nano dimension were …