Overcoming poor oral bioavailability using nanoparticle formulations–opportunities and limitations

PP Desai, AA Date, VB Patravale - Drug Discovery Today: Technologies, 2012 - Elsevier
Oral delivery of drugs with poor aqueous solubility and poor enzymatic and/or metabolic
stability is very challenging. However, the advent of nanotechnology has revolutionized the …

Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?

R Diab, C Jaafar-Maalej, H Fessi, P Maincent - The AAPS journal, 2012 - Springer
For the past few decades, there has been a considerable research interest in the area of oral
drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been …

Influence of particle geometry on gastrointestinal transit and absorption following oral administration

D Li, J Zhuang, H He, S Jiang, A Banerjee… - … applied materials & …, 2017 - ACS Publications
Geometry has been considered as one of the important parameters in nanoparticle design
because it affects cellular uptake, transport across the physiological barriers, and in vivo …

Nanoparticles in the clinic

AC Anselmo, S Mitragotri - Bioengineering & translational …, 2016 - Wiley Online Library
Nanoparticle/microparticle‐based drug delivery systems for systemic (ie, intravenous)
applications have significant advantages over their nonformulated and free drug …

Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology

J das Neves, RS Arzi, A Sosnik - Chemical Society Reviews, 2020 - pubs.rsc.org
Mucosal tissues constitute the largest interface between the body and the surrounding
environment and they regulate the access of molecules, supramolecular structures …

Facing the truth about nanotechnology in drug delivery

K Park - ACS nano, 2013 - ACS Publications
Nanotechnology in drug delivery has been manifested into nanoparticles that can have
unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors …

Insight into nanoparticle cellular uptake and intracellular targeting

B Yameen, WI Choi, C Vilos, A Swami, J Shi… - Journal of controlled …, 2014 - Elsevier
Collaborative efforts from the fields of biology, materials science, and engineering are
leading to exciting progress in the development of nanomedicines. Since the targets of many …

Targeted nanoparticles with novel non-peptidic ligands for oral delivery

A des Rieux, V Pourcelle, PD Cani… - Advanced drug delivery …, 2013 - Elsevier
Orally administered targeted nanoparticles have a large number of potential biomedical
applications and display several putative advantages for oral drug delivery, such as the …

Nanoparticles in the clinic: An update

AC Anselmo, S Mitragotri - Bioengineering & translational …, 2019 - Wiley Online Library
Nanoparticle drug delivery systems have been used in the clinic since the early 1990's.
Since that time, the field of nanomedicine has evolved alongside growing technological …

Nanotherapeutics in oral and parenteral drug delivery: Key learnings and future outlooks as we think small

P Tyagi, JA Subramony - Journal of Controlled Release, 2018 - Elsevier
Nanotechnology ushered the field of medicine in to a new era. Miniaturization, increased
surface area, and the unique physicochemical properties in the nano dimension were …