Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin

M Pietrzak, M Szabelski, G Wołąkiewicz… - Biophysical …, 2022 - Elsevier
The presented study was designed to estimate the ability of hypericin to interact with the
anticancer drug doxorubicin. The hetero-association of hypericin and doxorubicin was …

Interaction of a potential anticancer agent hypericin and its model compound emodin with DNA and bovine serum albumin

J Staničová, V Verebová, J Beneš - in vivo, 2018 - iv.iiarjournals.org
Background/Aim: We report the incorporation of prospective anticancer agent hypericin into
DNA and bovine serum albumin (BSA), respectively, with emphasis on comparison of the …

Interactions of hypericin with a model mutagen–Acridine orange analyzed by light absorption and fluorescence spectroscopy

M Pietrzak, M Szabelski, A Kasparek… - Chemical Physics …, 2017 - Elsevier
The present study was designed to estimate the ability of hypericin to interact with a model
mutagen–acridine orange. The hetero-association of hypericin and acridine orange was …

On the Diffusion of Hypericin in Dimethylsulfoxide/Water Mixtures The Effect of Aggregation

G Bánó, J Stanicová, D Jancura, J Marek… - The Journal of …, 2011 - ACS Publications
Hypericin (Hyp) is a natural photosensitizing pigment with a possible application in the
photodynamic therapy of cancer. Hyp is readily dissolved in dimethylsulfoxide (DMSO) but …

Influence of structure of human, rat, and bovine serum albumins on binding properties of photoactive drug hypericin

J Hritz, S Kascakova, J Ulicny… - … : Original Research on …, 2002 - Wiley Online Library
Fluorescence binding measurements and molecular modeling were employed to study the
interaction of hypericin (Hyp) with human (HSA), rat (RSA), and bovine (BSA) serum …

Subcellular distribution of hypericin in human cancer cells

P Miskovsky, F Sureau, L Chinsky… - Photochemistry and …, 1995 - Wiley Online Library
Confocal laser microspectrofluorometric measurements on human T47D mammary tumor
cells have been performed to assess the intracellular distribution of hypericin within the …

[PDF][PDF] Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole

A MIROŁŁAY, L Mirossay, M ŁARIŁSKÐ, P Papp… - Physiol. Res, 2002 - biomed.cas.cz
Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple
modes of light-induced biological activities due to production of singlet oxygen and/or …

Hypericin-a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules

P Miskovsky - Current drug targets, 2002 - ingentaconnect.com
Hypericin, a naturally occurring pigment, is found in certain species of plants from the genus
Hypericum, the most common of which is Saint John's Wort (Hypericum perforatum). Recent …

Surface-enhanced fluorescence and raman scattering study of antitumoral drug hypericin: an effect of aggregation and self-spacing depending on pH

G Lajos, D Jancura, P Miskovsky… - The Journal of …, 2008 - ACS Publications
Surface-enhanced fluorescence (SEF) and surface-enhanced Raman scattering (SERS)
techniques were applied in this work to study the ionization, aggregation, and adsorption …

How to make hypericin water-soluble

A Kubin, HG Loew, U Burner, G Jessner… - Die Pharmazie-An …, 2008 - ingentaconnect.com
Hypericin, isolated from Hypericum perforatum, is an effective photodynamic substance as
demonstrated by various studies. Practical forms of applications of hypericin solutions for …