Immunoprecipitates of metabolically labeled PC12 cells consistently contained a 43-kDa
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …

To assess a possible role for the Src homology 2 (SH2) domain adaptor protein Shb in PC12
cell signal transduction and differentiation, we have investigated the expression of Shb in …

Fetal rat brain (E18) expresses at least three c‐src‐like, membrane‐associated non‐
receptor tyrosine kinases: c‐src, fyn, and lyn. c‐src and fyn are the most abundant and are …

The adaptor protein Shc exists in three isoforms; p46, p52, and p66, and is a key regulator of
a variety of biological processes. Our previous studies have shown that the tyrosine kinase c …

Shc is an adaptor protein that contains two phosphotyrosine-binding domains, a Src
homology 2 (SH2) domain and the newly described phosphotyrosine interaction (PI) …

We have explored the role of the tyrosine kinase c-Src in cellular adhesion. Fibroblasts
derived from src-/-mice (src-/-fibroblasts) exhibit a reduced rate of spreading on fibronectin …

Shc is a ubiquitously expressed Src homology 2 (SH2) domain protein that can transform
fibroblasts and differentiate PC12 cells in a Ras-dependent fashion. Shc binds a variety of …

c-Src is normally associated with the plasma membrane, but upon activation by tyrosine
kinase receptors it translocates to the cytoskeleton. Activation of c-Src alters its conformation …

The Src homology 3 (SH3) domain, located in the amino-terminal, noncatalytic half of
pp60src, is highly conserved among members of the Src family of tyrosine kinases. SH3 …

She is an important signalling protein whose overexpression leads to cell transformation in
NIH 3T3 fibroblasts. Although the formation of Shc/Grb2 complexes involving Shc tyrosine …