Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells
D Thomas, SD Patterson, RA Bradshaw - Journal of Biological Chemistry, 1995 - ASBMB
Immunoprecipitates of metabolically labeled PC12 cells consistently contained a 43-kDa
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …
The Src homology 2 domain protein Shb transmits basic fibroblast growth factor-and nerve growth factor-dependent differentiation signals in PC12 cells.
T Karlsson, K Kullander, M Welsh - Cell Growth & Differentiation: the …, 1998 - europepmc.org
To assess a possible role for the Src homology 2 (SH2) domain adaptor protein Shb in PC12
cell signal transduction and differentiation, we have investigated the expression of Shb in …
cell signal transduction and differentiation, we have investigated the expression of Shb in …
Growth cone enrichment and cytoskeletal association of non‐receptor tyrosine kinases
S Helmke, KH Pfenninger - Cell motility and the cytoskeleton, 1995 - Wiley Online Library
Fetal rat brain (E18) expresses at least three c‐src‐like, membrane‐associated non‐
receptor tyrosine kinases: c‐src, fyn, and lyn. c‐src and fyn are the most abundant and are …
receptor tyrosine kinases: c‐src, fyn, and lyn. c‐src and fyn are the most abundant and are …
c-Src and phosphatidylinositol 3-kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
K Sato, T Otsuki, M Kimoto, M Kakumoto… - Biochemical and …, 1998 - Elsevier
The adaptor protein Shc exists in three isoforms; p46, p52, and p66, and is a key regulator of
a variety of biological processes. Our previous studies have shown that the tyrosine kinase c …
a variety of biological processes. Our previous studies have shown that the tyrosine kinase c …
Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (∗)
I Dikic, AG Batzer, P Blaikie, A Obermeier… - Journal of Biological …, 1995 - ASBMB
Shc is an adaptor protein that contains two phosphotyrosine-binding domains, a Src
homology 2 (SH2) domain and the newly described phosphotyrosine interaction (PI) …
homology 2 (SH2) domain and the newly described phosphotyrosine interaction (PI) …
c-Src enhances the spreading of src-/-fibroblasts on fibronectin by a kinase-independent mechanism.
We have explored the role of the tyrosine kinase c-Src in cellular adhesion. Fibroblasts
derived from src-/-mice (src-/-fibroblasts) exhibit a reduced rate of spreading on fibronectin …
derived from src-/-mice (src-/-fibroblasts) exhibit a reduced rate of spreading on fibronectin …
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
P Blaikie, D Immanuel, J Wu, N Li, V Yajnik… - Journal of Biological …, 1994 - Elsevier
Shc is a ubiquitously expressed Src homology 2 (SH2) domain protein that can transform
fibroblasts and differentiate PC12 cells in a Ras-dependent fashion. Shc binds a variety of …
fibroblasts and differentiate PC12 cells in a Ras-dependent fashion. Shc binds a variety of …
Overexpression of c-Src enhances cell-matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts
BS Verbeek, TM Vroom, G Rijksen - Experimental cell research, 1999 - Elsevier
c-Src is normally associated with the plasma membrane, but upon activation by tyrosine
kinase receptors it translocates to the cytoskeleton. Activation of c-Src alters its conformation …
kinase receptors it translocates to the cytoskeleton. Activation of c-Src alters its conformation …
An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain
M Rojas, S Yao, JP Donahue, YZ Lin - Biochemical and biophysical …, 1997 - Elsevier
She is an important signalling protein whose overexpression leads to cell transformation in
NIH 3T3 fibroblasts. Although the formation of Shc/Grb2 complexes involving Shc tyrosine …
NIH 3T3 fibroblasts. Although the formation of Shc/Grb2 complexes involving Shc tyrosine …
Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells
The Src homology 3 (SH3) domain, located in the amino-terminal, noncatalytic half of
pp60src, is highly conserved among members of the Src family of tyrosine kinases. SH3 …
pp60src, is highly conserved among members of the Src family of tyrosine kinases. SH3 …
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