G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent
evidence points toward their existence in vivo and their implication in various biological …

G-quadruplexes are nucleic acids secondary structures that can be formed in guanine-rich
sequences. More than 30 years ago, their formation was first observed in telomeric DNA …

Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions
regarding the possible presence and function of these intriguing structures in vivo remain …

The identification of novel cancer therapeutics is an intensive area of research that spans
interdisciplinary fields that includes biologists, chemists and clinicians. These fields have …

G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

G-quartets are square planar arrangements of four guanine bases, which can form
extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex …

G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …

Although DNA is most widely known for its ability to store and pass along genetic
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …

Accumulating evidence has linked G-quadruplex structures to a number of biological
processes in vivo, including DNA replication, transcription, and genomic maintenance …