In the ubiquitin system, a target substrate is modified by ubiquitin or a ubiquitin‐like protein.
This modification remodels the surface of the target proteins, affecting, among other …

Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular
processes. Among these are regulation of cell cycle and division, modulation of the immune …

Translation of the genetic code to proteins was a main focus of biological research before
the 1980s. How proteins are removed had remained a neglected area of research. With the …

Ubiquitin modification of many protein targets within cells plays important roles in a variety of
biological processes. Among these are regulation of gene expression, regulation of cell …

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to
a variety of intracellular proteins that bear degradation signals recognized by this system …

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein
degradation pathways in mammalian cells: the proteasome, the lysosome, and the …

Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …

The ubiquitin proteolytic system plays an important role in a broad array of basic cellular
processes. Among these are regulation of cell cycle, modulation of the immune and …