Neutrophils are potent contributors to the lung pathophysiological changes occurring in
allergic airway inflammation, which typically involve T helper type 2 (Th2) cytokine …

Background Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC).
Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity …

Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are
key actors in host defense, migrating toward sites of inflammation and infection, where they …

Heaves in horses shares many similarities with human asthma, including lower airway
inflammation, reversible airway obstruction, and bronchial hyperresponsiveness. Extrinsic …

Little is known concerning the possible contribution of T helper 2 (Th2)-type cytokines to the
recruitment of neutrophils into the lung tissue. In the present study, endothelial cells from …

Asthma is a common and debilitating chronic airway disease that affects people and horses
of all ages worldwide. While asthma in humans most commonly involves an excessive type …

Background Glucocorticoids (GCs) are the most effective drugs for the treatment of human
asthma. However, a subgroup of asthmatic patients with neutrophilic airway inflammation is …

Background Neutrophil apoptosis and phagocytic clearance have been proposed as key
determinants affecting the resolution of airway inflammation. Objective To determine the …

Horses are susceptible to a multitude of inflammatory conditions that are characterized by a
strong neutrophilic response. Here, we review basic equine neutrophil biology and explore …

Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …