Reactive oxygen species (ROS) have an established role in inflammation and host defense,
as they kill intracellular bacteria and have been shown to activate the NLRP3 …

In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive
oxygen species (ROS), followed by an antioxidant response involved in IL-1β processing …

TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the
pathogenesis of many inflammatory diseases. TNFR-associated periodic syndrome (TRAPS …

Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal
dominant autoinflammatory syndrome characterized by prolonged and recurrent episodes of …

Tumor necrosis factor (TNF) receptor–associated periodic syndrome (TRAPS) is an
autosomal dominant systemic autoinflammatory disease associated with heterozygous …

Inflammation is associated with the release of soluble mediators that drive cellular activation
and migration of inflammatory leukocytes to the site of injury, together with endothelial …

The two best-characterized types of CD4+ regulatory T cells (Tregs) are Foxp3+ Tregs and
Foxp3− type 1 regulatory (Tr1) cells. The ability of Foxp3+ Tregs and Tr1 cells to suppress …

Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form
inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

The danger signals that activate the NLRP1 inflammasome have not been established.
Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to …