OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

Antidepressant medications generally are considered to have a delayed onset of action;
however, recent evidence is beginning to challenge this conventional wisdom. Meta …

RATIONALE: Treatment guidelines for major depressive disorder (MDD) recommend a
continuous use of antidepressants for several weeks, while recent meta-analyses indicate …

Although various published clinical studies have suggested that some antidepressants may
have a more rapid onset of therapeutic effect than others, none of these trials was …

There is still considerable controversy about the onset and time course of improvement with
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …

BACKGROUND: Delayed onset of efficacy of antidepressants and a high proportion of
depressed patients being poor or non-responders to antidepressants are well known clinical …

BACKGROUND: The full response to antidepressant pharmacotherapy is evident only after
several weeks, but considerable improvements may already be visible within the first two …

Background: For years, investigators have tried to determine the speed of onset of
antidepressant drugs. Claims that particular drugs may produce a faster response in patients …

In standard drug trials comparing antidepressants with placebo, a period of typically 3 weeks
is required before formal statistical significance between treatments is achieved. This delay …

Rationale Traditionally, the therapeutic effect of antidepressants is thought to take several
weeks. However, several studies found evidence of early drug response occurring within the …