The onset of action of antidepressant medications is commonly believed to require three or
more weeks based on clinical observation and corollary receptor-based hypotheses …

Research on accelerating the response to antidepressants has focused attention on the
possibility of fast-acting antidepressants. A major advance has been the development of …

Objective: To examine the available scientific evidence for answers to clinically relevant
questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long …

Objective: In clinical practice, acute antidepressant treatment is often applied for several
months until remission is achieved. However, data on treatment outcomes beyond 8 weeks …

Background Meta-analyses of antidepressant medications have reported only modest
benefits over placebo treatment, and when unpublished trial data are included, the benefit …

BACKGROUND: The duration of untreated illness has been considered a likely predictor of
the course of psychotic disorders. However, there is only sparse data concerning the …

The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …

Many sources purport that antidepressants have a delayed onset of action, measured in
weeks rather than days. Recent data using weekly or daily mood ratings demonstrate that …

Currently available antidepressants used to treat major depressive disorder (MDD)
unfortunately often take weeks to months to achieve their full effects, commonly resulting in …

Depression is a serious and burdensome illness. Although selective serotonin reuptake
inhibitors (SSRIs) have improved safety and tolerability of antidepressant treatment efficacy …