In the treatment of depression, there is considerable interest in the time course of response
and, in particular, the speed with which individuals recover from depressive episodes …

Objective: Antidepressants (ADs) are the mainstay of treatment for major depressive
disorder (MDD). Despite their widespread usage, a consensus does not exist as to the …

Objective: While there is some indication from studies in the acute phase of antidepressant
treatment that there are differences in the timing of improvement in symptoms, relatively little …

Objective:(1) To directly compare the effectiveness of switching antidepressants with
augmenting them in depressed patients who do not respond to an initial adequate trial and …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …

Recent pairwise meta-analysis including only double-blind, randomized placebo-controlled
trials (DBRPCTs) with an enrichment design in which individuals with MDD were stabilized …

Background To compare response to antidepressants between randomized controlled trials
(RCTs) and observational trials. Methods and Findings Published and unpublished studies …

Background The efficacy, limitations, and methods of studying antidepressant treatment
continued beyond initial weeks of acute major depression remain incompletely resolved …

The probability of achieving and sustaining symptomatic remission in major depressive
disorder (MDD) with first-line pharmacotherapy is approximately 30%. Ample documentation …

Objective Antidepressant switch is a commonly used strategy in the absence of an adequate
response, but optimum timing is not well established. We compared the efficacy of an early …